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Search Results for " orphan g-protein coupled receptor "

Targets Recommended: GPR

23

抑制剂 & 化合物

1

化合物库

6

重组蛋白

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Cat. No.	Product Name
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T23204	PSN 375963 PSN 375963 hydrochloride	GPR	Endocrinology/Hormones; GPCR/G Protein
	PSN 375963 (PSN 375963 hydrochloride) hydrochloride 是GPR119激动剂，对人和小鼠的EC50分别为 8.4 和 7.9 μM。它表现出与内源性油酰乙醇酰胺 (OEA) 相似的效力。
T5422	CID 1375606 CID-1375606,CID1375606	Others	Others
	CID 1375606 是孤儿 G 蛋白偶联受体GPR27的代理激动剂。
TP2073L	BigLEN (mouse) acetate BigLEN (mouse) acetate (501036-69-7 Free base)	GPR	Endocrinology/Hormones; GPCR/G Protein
	BigLEN (mouse) acetate 是一种有效的、选择性的孤儿 G 蛋白偶联受体 171 (GPR171) 激动剂，Kd 为 ~0.5 nM。
T19700	IBC 293 IBC293,1-异丙基-1H-1,2,3-苯并噻唑-5-羧酸,IBC-293	GPR	Endocrinology/Hormones; GPCR/G Protein
	IBC 293 对 GPR109B 的选择性高于烟酸受体 GPR109A。 IBC 293 是 GPR109B 的高选择性激动剂，GPR109B 是一种在脂肪细胞中表达的人类孤儿 G 蛋白偶联受体。
TP1982L	Neuropeptide S (Rat) acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Neuropeptide S (Rat) acetate 是以前孤儿 G 蛋白偶联受体的内源性配体，现在称为 NPS 受体。它可用于神经系统疾病的研究。
T60199	NCRW0005-F05	GPR	Endocrinology/Hormones; GPCR/G Protein
	NCRW0005-F05 是一种有效的孤儿 G 蛋白偶联受体GPR139的激动剂，IC50为 0.21 μM。NCRW0005-F05 可用于研究糖尿病、肥胖症和帕金森的研究。
T70771	PSB-1737
	PSB-1737 is a Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17 (EC50 270 nM).
T68805	PSB-1584
	PSB-1584 is a Potent Agonist of the Orphan G Protein-Coupled Receptor 84 (GPR84). GPR84, a Gi protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer.
T68247	PSB-KD107
	PSB-KD107 is an agonist of the Cannabinoid-Activated Orphan G‑Protein-Coupled Receptor GPR18. PSB-KD107 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55.
T83547	(Des-Bromo)-Neuropeptide B (1-23) (human)
	'(Des-Bromo)-Neuropeptide B (1-23) (human)' 是一种作用于orphan G-protein coupled receptor的激动剂，对GPR7 (NPBW1) 的Ki值为1.2 nM，而对GPR8 (NPBW2) 的Ki值则为341 nM。
T75961	Urotensin II, mouse TFA
	Urotensin II, mouse TFA 为孤儿G蛋白偶联受体GPR14或SENR的内源性配体，具有强效血管收缩作用，并在中枢神经系统中发挥重要角色。
T75962	Urotensin II, mouse acetate
	Urotensin II, mouse acetate，是孤儿G蛋白偶联受体（GPR14或SENR）的一种内源性配体，具有显著的血管收缩活性并在中枢神经系统中发挥重要功能。
T81683	Neuromedin S (human)
	Neuromedin S (human) 是包含33个氨基酸的神经肽，作为G 蛋白偶联受体 (GPCR) FM-4/TGR-1的内源性配体，在大脑中被鉴定，并对神经调节素 U (NMU) 受体 2 (NMUR2)调节体重稳态具有调控作用。
T83743	VPM-p15 TFA T1V/F3Phe(4-Me)
	VPM-p15是一种合成多肽激动剂，针对粘附G蛋白偶联受体(GPCR) G2 (ADGRG2)而设计，ADGRG2是一种孤儿GPCR，与男性不育有关。在表达人类ADGRG2的HEK293细胞中，它能诱导cAMP积累（EC50 = 1.41 µM）。
T69612	PSB-KD477
	PSB-KD477 is an Agonist of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. PSB-KD477 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55. Structure-activity relationships were steep, and indole substitution was crucial for biological activity. These first selective agonists, which are structurally distinct from the lipidic...
T75925	Orexin B, rat, mouse TFA
	Orexin B, rat, mouse (Rat orexin B) TFA，作为一种内源性促进食欲的(Orexin receptor)激动剂，通过结合并激活两个亲密相关的孤儿G蛋白偶联受体OX1-R和OX2-R，促进食物摄入和能量消耗，并在睡眠-觉醒调节中扮演关键角色。
T75784	Apelin-36(rat, mouse) TFA
	Apelin-36(rat, mouse) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-36(rat, mouse) TFA 与 APJ 受体结合，IC50为 5.4 nM，显著抑制 cAMP 的产生，EC50为 0.52 nM。Apelin-36(rat, mouse) TFA 阻断 HIV-1和 HIV-2毒株进入表达 APJ 的 NP-2/CD4 细胞。
T75785	Apelin-17(human, bovine) TFA
	Apelin-17(human, bovine) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂。Apelin-17(human, bovine) TFA 与在 HEK 293 细胞中表达的人 APJ 受体结合 (pIC50)。Apelin-17(human, bovine) TFA 阻断 HIV-1和 HIV-2毒株进入表达 APJ 的 NP-2/CD4 细胞。
T75783	Apelin-36(human) TFA
	Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂，EC50为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA 与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1和 HIV-2进入表达 APJ 的 NP2/CD4细胞。
T35794	Kisspeptin-54 (human) (trifluoroacetate salt)
	Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...
T83926	S-Geranylgeranyl-L-glutathione GGG
	S-Geranylgeranyl-L-glutathione是孤儿G蛋白偶联受体（GPCR）P2RY8的配体。该化合物在100 nM浓度下，选择性地诱导P2RY8而非鞘氨醇-1-磷酸受体2（S1P2）、GPR55、半胱氨酸白三烯受体1（CysLT1 receptor）以及CysLT2 receptor的内吞作用。在10 nM浓度下，S-Geranylgeranyl-L-glutathione抑制了表达P2RY8的WEHI-231 B细胞淋巴瘤细胞和分离的人扁桃体生发中心B细胞由趋化因子（C-X-C motif）配体12（CXCL12）诱导的迁移。
T37187	D-erythro/L-threo Lysosphingomyelin (d18:1) D-erythro/L-threo Lysosphingomyelin (d18:1)
	Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O...
T35597	Neuromedin U-23 (rat) (trifluoroacetate salt)
	Neuromedin U-23 (NMU-23) is a neuropeptide involved in diverse biological processes, including smooth muscle contraction, energy homeostasis, and nociception.1It is an agonist of neuromedin-U receptor 1 (NMUR1; EC50= 0.17 nM for the human receptor in a calcium mobilization assay using HEK293 cells) and NMUR2 (EC50= ~1.4-2 nM for arachidonic acid release in CHO cells expressing the human receptor).2,3NMU-23 (1 μM) induces contractions in isolated rat colon smooth muscle strips.4It decreases body ...

化合物

Cat.No: T23204

Synonym: PSN 375963 hydrochloride

Target: GPR

Cat.No: T5422

Synonym: CID-1375606,CID1375606

Target: Others

BigLEN (mouse) acetate

Cat.No: TP2073L

Synonym: BigLEN (mouse) acetate (501036-69-7 Free base)

Target: GPR

Cat.No: T19700

Synonym: IBC293,1-异丙基-1H-1,2,3-苯并噻唑-5-羧酸,IBC-293

Target: GPR

Neuropeptide S (Rat) acetate

Cat.No: TP1982L

Target: Neuropeptide Y Receptor

Cat.No: T60199

Target: GPR

Cat.No: T70771

Cat.No: T68805

Cat.No: T68247

(Des-Bromo)-Neuropeptide B (1-23) (human)

Cat.No: T83547

Urotensin II, mouse TFA

Cat.No: T75961

Urotensin II, mouse acetate

Cat.No: T75962

Neuromedin S (human)

Cat.No: T81683

Cat.No: T83743

Synonym: T1V/F3Phe(4-Me)

Cat.No: T69612

Orexin B, rat, mouse TFA

Cat.No: T75925

Apelin-36(rat, mouse) TFA

Cat.No: T75784

Apelin-17(human, bovine) TFA

Cat.No: T75785

Apelin-36(human) TFA

Cat.No: T75783

Kisspeptin-54 (human) (trifluoroacetate salt)

Cat.No: T35794

S-Geranylgeranyl-L-glutathione

Cat.No: T83926

Synonym: GGG

D-erythro/L-threo Lysosphingomyelin (d18:1)

Cat.No: T37187

Synonym: D-erythro/L-threo Lysosphingomyelin (d18:1)

Neuromedin U-23 (rat) (trifluoroacetate salt)

Cat.No: T35597

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01193	GPRC5D Protein-VLP, Mouse, Recombinant MGC129713,orphan G-protein	Mouse	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Mouse, R...
TMPK-00528	GPRC5D Protein-VLP, Cynomolgus, Recombinant MGC129713,GPRC5D,MGC129714,or...	Cynomolgus	HEK293 Cells
	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolg...
TMPY-04270	GPR133 Protein, Human, Recombinant (His) PGR25,GPR133	Human	HEK293 Cells
	ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1, an orphan member of the adhesion family of G-protein-coupled receptors, is a critical regulator of the response to hypoxia and tumor growth in Glioblastoma (GBM). ADGRD1 represents a novel molecular target in GBM and possibly other malignancies where hypoxia is fundamental to pathogenesis. Variations in the ADGRD1 locus are linked with...
TMPY-02717	GPR37 Protein, Human, Recombinant (His) hET(B)R-LP,PAELR,G protein-coupled	Human	HEK293 Cells
	GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and n...
TMPK-01411	Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated Peptide Ready,HLA-G,MHC	Human	HEK293 Cells
	Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01418	Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi) MHC,HLA-G,Peptide Ready	Human	HEK293 Cells
	Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.

重组蛋白

GPRC5D Protein-VLP, Mouse, Recombinant

Cat.No: TMPK-01193

Species: Mouse

Expression System: HEK293 Cells

GPRC5D Protein-VLP, Cynomolgus, Recombinant

Cat.No: TMPK-00528

Species: Cynomolgus

Expression System: HEK293 Cells

GPR133 Protein, Human, Recombinant (His)

Cat.No: TMPY-04270

Species: Human

Expression System: HEK293 Cells

GPR37 Protein, Human, Recombinant (His)

Cat.No: TMPY-02717

Species: Human

Expression System: HEK293 Cells

Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01411

Species: Human

Expression System: HEK293 Cells

Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01418

Species: Human

Expression System: HEK293 Cells

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